MSC is located on Talpur Road (formerly Woods Street), within the limits of the historic Railways Quarter. The original property functioned as a warehouse building during the colonial period. Today, the only vestiges that remain of the warehouse are the stone boundary walls. In accordance with the character of the area, the boundary wall and the frontage of the entrance have been restored to preserve their architectural heritage. TDF MagnifiScience Centre is an amalgamation of the past and the present—historical and modern—in its architectural design.